| Date | Location | Result | |
| Nov 13, 2010 | Grand Junction, CO | Chadron State 31, Mesa State College 21 | Box score |
| Nov 06, 2010 | Alamosa, CO | Adams State 41, Mesa State College 34 | Box score |
| Oct 30, 2010 | Grand Junction, CO | Mesa State College 33, Western State 28 | Box score |
| Oct 23, 2010 | Grand Junction, CO | CSU-Pueblo 26, Mesa State College 14 | Box score |
| Oct 16, 2010 | Golden, CO | Colorado Mines 46, Mesa State College 10 | Box score |
| Oct 09, 2010 | Grand Junction, CO | Mesa State College 31, Ft. Lewis 14 | Box score |
| Oct 02, 2010 | Silver City, NM | Western New Mexico 20, Mesa State College 10 | Box score |
| Sep 25, 2010 | Grand Junction, CO | Mesa State College 40, N.M. Highlands 6 | Box score |
| Sep 18, 2010 | Kearney, NE | Nebraska Kearney 31, Mesa State College 9 | Box score |
| Sept 2, 2010 | St. Joseph, Mo. | Missouri Western 36, Mesa State College 3 | Box score |